I'd also say that this looks like an incompatibility with the OS used on the Vampire. However, you can do a manual installation of Hollywood Designer like this:
1) Create a "Designer" directory somewhere on your HD
2) Copy all files from the "Data" to the "Designer" directory
3) Copy the file "Designer" from Platform/AmigaOS3 to the "Designer" directory
4) Copy the file "Designer.key" to the "Designer" directory
5) Copy the icons from Icons/GlowIcons to the "Designer" directory
6) Copy the catalogs from the "Locale" directory to LOCALE:Catalogs
7) Add a "Designer:" assign that points to your "Designer" directory to S:User-Startup
Then reboot and it should work
